MTHFR and LC, CFS, POTS, MCAS, SIBO, EDS: Methylating the Alphabet Article (Preprint v1) by Patrick Chambers Qeios MCAS Bundle Consult Dr. Anderson Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis ScienceDirect Multiomics reveals glutathione metabolism as a driver of bimodality during stem cell aging ScienceDirect Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione.