Item Scheme showing the enzymatic reactions that catalyze the pyruvate dehydrogenase complex, including pyruvate dehydrogenase activity and diaphorase activity of DLD (A) as well as the glutathione reductase peroxidase activity (B). Glutathione System from Cyanobacteria to Higher Eukaryotes Encyclopedia MDPI Glutathione NADPH + H+ NADP+ FAD Pentose Phosphate Pathway Riboflavin Glutamate (Oxidized glutathione) (Reduced glutathione, a s Structure and mechanism of mammalian thioredoxin reductase: The active site is a redox active selenolthiol selenenylsulfide formed from the conserved cysteine selenocysteine sequence PNAS Contribution of Fdh3 and Glr1 to Glutathione Redox State, Stress Adaptation and Virulence in Candida albicans PLOS One