Labial Lentigo (labial melanotic macule) Cancer Therapy Advisor Definition of melanocytic macules associated with Peutz Jeghers syndrome NCI Dictionary of Genetics Terms NCI Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule. AD :: Annals of Dermatology Labial or Oral Melanotic Macule Benign, asymptomatic, and often underdiagnosed. Swipe to learn how to recognize, diagnose, and manage this simple yet important lesion! #thebasicdentist #rguhs #kuhs #tnmgrmu #OralPathology #MelanoticMacule #DentalFacts