Assessment of the aversive consequences of acute and chronic administration of the melanocortin agonist, MTII International Journal of Obesity Mucosal melanocytic macules Labial melanotic macule A melanocortin 4 and glucagon like peptide 1 receptor multiple agonist for the treatment of diabetes and obesity ScienceDirect An oral melanotic macule is a harmless dark spot found on the lip, most often the lower lip, or inside the mouth, either on the gums, inside the cheek, or on the roof of the mouth. An oral melanotic