Glutathione Reductase human Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Managing Mast Cell Activation Syndrome (MCAS) Stabilizers AZD5904 Olive leaf extract (OLE) reduces mast cell mediated allergic inflammation ScienceDirect