Is focal melanotic lesion potentially malignant? A case report ScienceDirect Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Pathology Outlines Melanotic macule Pigmented Lesions of the Oral Cavity Pocket Dentistry This lovely patient was thrilled with her beautiful result after laser treatment of oral melanotic macules. I share this case to educate: laser treatment requires accurate diagnosis, an understanding