Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Protective effect of apigenin on mouse acute liver injury induced by acetaminophen is associated with increment of hepatic glutathione reductase activity Food & Function (RSC Publishing) Clinical and Experimental Pediatrics Illustration of the effects of acetaminophen on glutathione, Download Scientific Diagram View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine