Why you should avoid REGULAR acetaminophen use for babies and pregnancy 3 Little Plums Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Common Medications That Rob the Body of Nutrients Wellness Resources Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Gender specific changes in energy metabolism and protein degradation as major pathways affected in livers of mice treated with ibuprofen Scientific Reports