The mechanism of acetaminophen action! The mechanism of action of acetaminophen (paracetamol), a common analgesic, is not yet clear. The study shows that acetaminophen counterintuitively inhibits diacylglycerol lipase (DAGL), but not Exploring N Acetylcysteine in Psychiatry Psychiatric Times Glutathione You Are The Healer Acetylcysteine Injection Effective Antidote & Mucolytic Solution at Best Price Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.