NSAIDs & Acetaminophen Clinical Pharmacology Flashcards ditki medical and biological sciences Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Don't Suppress a Fever Acetaminophen detoxification in cucumber plants via induction of glutathione S transferases ScienceDirect Metabolism of acetaminophen (paracetamol) in plantstwo independent pathways result in the formation of a glutathione and a glucose conjugate Environmental Science and Pollution Research Springer Nature Link