Frontiers Acetaminophen induced liver injury: Molecular mechanism and treatments from natural products g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. sagesteele @P_McCulloughMD While I dont know whether there is a connection between Tylenol and autism, I do believe that there is reason to STOP giving it to babies children. Glutathione is impacted by Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health