A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Acetaminophen's Role in Autism and ADHD: A Mitochondrial Perspective Longterm adverse effects of paracetamol a review McCrae 2018 British Journal of Clinical Pharmacology Wiley Online Library An Example of a Drug That Causes Toxicity Through the Formation of a Chemically Reactive Intermediate Mechanisms of Adverse Drug Reactions Pharmacovigilance Pharmacology 401 k Paracetamol NAPQI Glutathione COX3 Poisoning Antidote AcetylCysteine
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paracetamol and glutathione depletion Acetaminophen toxicity