Frontiers Growth hormone insulin like growth factor I axis in health and disease states: an update on the role of intra portal insulin Figure 1 from Intranasal Human Growth Hormone (hGH) Induces IGF 1 Levels Comparable With Subcutaneous Injection With Lower Systemic Exposure to hGH in Healthy Volunteers Semantic Scholar How GHK Peptide Works Signaling GHK acts as a switch for skin repair: Interacts with adenosine receptors reduces inflammation Activates MAPK ERK, PI3K Akt, TGF pathways Stimulates fibroblasts & keratinocytes boosts collagen, elastin The relations between GH, IGF 1, Klotho, inflammation and Download Scientific Diagram How GHK Peptide Works Signaling GHK acts as a switch for skin repair: Interacts with adenosine receptors reduces inflammation Activates MAPK ERK, PI3K Akt, TGF pathways Stimulates fibroblasts & keratinocytes boosts collagen, elastin