Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Dose dependent effects of acetaminophen and ibuprofen on mitochondrial respiration of human platelets Molecular and Cellular Biochemistry Springer Nature Link Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism of acetaminophen and Current Insights into Glutathione Depletion in Adult Septic Patients