Paracetamol toxicity Deranged Physiology Clinically relevant therapeutic approaches against acetaminophen hepatotoxicity and acute liver failure ScienceDirect Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen toxicity EMCrit Project Researchers are studying a possible link between acetaminophen (Tylenol) use during pregnancy and higher autism or ADHD risk. It may lower glutathione, an important antioxidant for brain development.