In the process of removing a Labial Melanotic Macule. A Labial Melanotic Macule is a well defined, oval, brown to black, flat patch on the central third of the lower lip, as seen Labial melanotic macule (brown spot on lip) (Stony Brook Case 1) dermatology dermatopathology Labial Melanotic Macules in Atopic Dermatitis: An Observational Study Semantic Scholar Dermoscopy of venous lake on the lips: A comparative study with labial melanotic macule PLOS One This patient has multiple labial melanotic macules. These are essentially freckles of the lips. These most commonly involve the lower lip. This patient had involvement of both the upper and lower lips.