Most kidney patients are focused on creatinine while almost nobody is talking about what's happening inside the kidney cells. That's where NAC and ALA become interesting. Because kidney disease is not just Glutathione depletion induces oxidative injury and apoptosis via TRPM2 channel activation in renal collecting duct cells ScienceDirect Frontiers Natural products for kidney disease treatment: Focus on targeting mitochondrial dysfunction Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic Metabolomic Study of Kidney Injury Induced by Antitubercular Drugs and Therapeutic Effect of Glutathione Based on Gas Chromatography Mass Spectrometry ScienceDirect