Tylenol's Impact on Glutathione and Liver Damage A Possible Antidote for Tylenol (Paracetamol) Overdose American Council on Science and Health Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism of acetaminophen and Acetaminophen Pathway (therapeutic doses), Pharmacokinetics Tylenol's Impact on Glutathione and Liver Damage