Can You Donate Blood If You Smoke? What You Should Know Dr. Karuna Kumar Smoking (or vaping) doesn't affect your ability to donate blood. Help us bust this myth by sharing our post. YES, you can donate blood if you smoke or consume cannabis. Let's break the stigma! , All donors go through the same health screening. All blood donations are tested for several types of infections, Yes, you can donate blood if you smoke or consume cannabis. The recipient of the blood will not get high, another common MYTH. All donors go through the same health Can you donate blood if you smoke?