Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Acetaminophen or Tylenol Toxicity Lect 19 Pharmacology Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury Vliegenthart 2017 Clinical Pharmacology & Therapeutics Wiley Online Library Illustration of the effects of acetaminophen on glutathione, Download Scientific Diagram
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glutathione and tylenol toxicity Tylenol's Impact on Glutathione and Liver Damage