Cagrilintide: The Next Gen Peptide for Weight Loss and Satiety Hubmed Cagrilintide is an amylin analogue that helps regulate appetite. In a randomized trial of over 3400 patients who were overweight or obese and had 1 weight related complication, individuals assigned to a combination CagriSema Reduces Blood Pressure in Adults With Overweight or Obesity: REDEFINE 1 Hypertension Cagrilintide: The Next Gen Peptide for Weight Loss and Satiety Hubmed How does CagriSema (Cagrilintide) Work?