What if neuroplasticity research targeted the HGF c Met pathway? Dihexa (PNB 0408) is an angiotensin IVderived peptide studied in preclinical models for its role in synaptogenesis and cognitive signaling mechanisms. Human data remains limited. What is dihexa, its mechanism of action via the HGF c Met pathway, and its safety and clinical use? Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted A novel agonist for the HGF receptor MET promotes differentiation of human pluripotent stem cells into hepatocytelike cells Tauran 2022 Development, Growth & Differentiation Wiley Online Library Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted