The effectiveness of compound X is oftentimes dependent on the presence of compounds Y and Z and so on. Endogenous compounds like glutathione get a lot of commercial attention but they do Glutathione adducts induced by ischemia and deletion of glutaredoxin 1 stabilize HIF 1 and improve limb revascularization PNAS Glutathione For Autoimmune Disease How To Make More Of It Dr. Hagmeyer Dr Hagmeyer S Glutathionylation: From Molecular Mechanisms to Health Outcomes Ying Xiong, Joachim D. Uys, Kenneth D. Tew, Danyelle M. Townsend, 2011 Dynamics of host glutathione and glutathione related enzymes in Macrophomina phaseolina sorghum bicolor interaction bioRxiv