Carnitine Metabolism and Its Role in Fatty Acid Oxidation Creative Proteomics Medium chain fatty acid oxidation is independent of l carnitine in liver and kidney but not in heart and skeletal muscle American Journal of Physiology Gastrointestinal and Liver Physiology American Physiological Society L Carnitine plays an important role in the larger metabolism equation: helping your body use fat efficiently as fuel. Learn more about the science on this week's post on The Wellness Edit. L Carnitine is Underrated. New Meta Review Reminds Us Why. Hepatic Carnitine Palmitoyltransferase (CPT) System: Gateway to Fatty Acid Oxidation Long chain fatty acids cannot directly cross the inner mitochondrial membrane. The hepatic carnitine shuttle system, led by CPT I and