Clinically important side effects of Melanotan II and placebo Download Table Melanotan 2 Day 4: Whacky Side Effects. , I am cutting back from daily use and probably using once a week from here on out. , Zero appetite, Fatigue, And what I think was sleep paralysis , And yes Avoid nasal tanning sprays or nasal tanners entirely. These products promise an all over tan without sun exposure but they are unregulated, can be unsafe, and contain potentially risky substances like Melanotan 2. No, you don't need the 'Barbie drug' to tan, whatever TikTok says. Here's why melanotan II is so risky Melanotan 1 vs. 2: My Summer Journey & Real Results