Cagrilintide is an amylin analogue that helps regulate appetite. In a randomized trial of over 3400 patients who were overweight or obese and had 1 weight related complication, individuals assigned to a combination Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide 24 mg for weight management: a randomised, controlled, phase 1b trial ScienceDirect Obesity Week 2025 Medications Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors Nature Communications Combined GLP 1 amylin analog bests monotherapy for HbA1c drop, weight loss in diabetes