This is happening whether you feel it or not. Your cells are constantly producing damage and glutathione is what keeps that in check. But stress, poor sleep, and toxic load? They burn Depletion of hepatic glutathione and adenosine by glucocorticoid exposure in Wistar rats is pregnancy independent ScienceDirect Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic Glutathione depletion induces oxidative injury and apoptosis via TRPM2 channel activation in renal collecting duct cells ScienceDirect Acute kidney injury model established by systemic glutathione depletion in mice Matsubara 2019 Journal of Applied Toxicology Wiley Online Library